Ephron writes about falling hard for a way of life ("Journalism: A Love Story") and about breaking up even harder with the men in her life ("The D Word"); lists "Twenty-five Things People Have a Shocking Capacity to Be Surprised by Over and Over Again" ("There is no explaining the stock market but people try"; "Cary Grant was Jewish"; "Men cheat"); reveals the alarming evolution, a decade after she wrote and directed "You've Got Mail," of her relationship with her in-box ("The Six Stages of E-Mail"); and asks the age-old question, which came first, the chicken soup or the cold? All the while, she gives candid, edgy voice to everything women who have reached a certain age have been thinking . . . but rarely acknowledging.