French Professor Aronnax and his servant join the Abraham Lincoln, an American frigate, on a mission to find and destroy a "sea-unicorn of colossal dimensions, armed not with a halberd, but with a real spur, as the armored frigates." The undersea monster is thought to be responsible for the disappearance of over 200 ships. When they encounter the "gigantic cetacean" it disables the Abraham Lincoln and knocks Professor Aronnax, his servant, and the hot-tempered harpooner, Ned Land overboard. The three must cling to the beast or drown; soon they realize that it is really a man-made underwater vehicle.

Captain Nemo captures the men on his incredible submarine, the Nautilus. The captain and his unwilling passengers thus embark on a deep-sea odyssey that stretches from the palm-strewn Indian Ocean to the frozen peril of the South Pole. But the enigmatic Nemo has a darker purpose for his voyage...revenge on humanity.