Turgenev wrote Fathers and Sons as a response to the growing cultural schism that he saw between liberals of the 1830s/1840s and the growing nihilist movement. Both the nihilists (the "sons") and the 1830s liberals sought Western-based social change in Russia. Additionally, these two modes of thought were contrasted with the conservative Slavophiles, who believed that Russia's path lay in its traditional spirituality.

Fathers and Sons might be regarded as the first wholly modern novel in Russian Literature (Gogol's Dead Souls, another main contender, is sometimes referred to as a poem or epic in prose as in the style of Dante's Divine Comedy). The novel introduces a dual character study, as seen with the gradual breakdown of Bazarov's and Arkady's nihilistic opposition to emotional display, especially in the case of Bazarov's love for Madame Odintsova and Fenichka. This prominent theme of character duality and deep psychological insight would exert an influence on most of the great Russian novels to come, most obviously echoed in the novels of Tolstoy and Dostoevsky.