October 17, 2003: A night no Yankees or Red Sox fan will ever forget. At 12:15 am, bottom of the eleventh inning of game seven of the ALCS, New York third-baseman Aaron Boone launches a ball over Yankee Stadium's left-field fence. The Yankees win their 39th pennant, and send the perennially vexed Boston Red Sox home...again...suffering another devastating loss to their longtime nemesis.

October 20, 2004: A year later, an eerie reprise, but this time things are different. After losing three straight to the Yankees, Boston has charged back to win the next three, forcing a decisive game seven. From the start of the game Boston is in control, and by winning this game they march toward their first World Series victory since 1918.

With the razor-sharp instincts that have made him a top sports journalist, Mike Vaccaro delves into the history of the rollicking rivalry: a vicious collision in 1903 that draws first blood; the era of Babe Ruth and his legendary trade from the Red Sox to the Yankees, ushering in the notorious Curse; the golden age of DiMaggio and Williams; the unstoppable power of Mantle and Maris; the heart and soul of Fisk and Yazstremski versus Pinella and Munson; and the modern era of dueling owners, skyrocketing payrolls, and a renewed rivalry that attracts sell-out crowds even to Yankees-Red Sox spring training games.