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Futures in Biotech Podcast by Marc Pelletier

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Futures in Biotech 49: Brain-Machine Interfaces

leo@leoville.com (Leo Laporte) Author: Marc Pelletier and Dave Brodbeck
Tue, Nov 17, 2009

Hosts: Dr. Marc Pelletier and Dr. Kirsten Sanford

Guests Dr. Justin Sanchez Assistant Professor of Pediatrics, Neuroscience, and Biomedical Engineering, and Biomedical Engineering, University of Florida

Dr. Justin Sanchez walks us through the technology of brain machine interfaces.

Show notes

Comments and suggestions on Futures in Biotech.

For a free audiobook, visit Audible.com/biotech.

Transcripts to the shows are available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:05:24

Hosts: Dr. Marc Pelletier and Dr. Andre Nantel

Guests: Edward Delong, Ph.D.

Dr. Delong discusses the use of metagenomics to understand microbial life in the Pacific Ocean.

Show notes

Comments and suggestions on Futures in Biotech.

For a free audiobook, visit Audible.com/biotech.

Transcripts to the shows are available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 51:12">

Host: Dr. Marc Pelletier

Guests: Dr. Andre Nantel, Ph.D. and Dr. Oliver Smithies

Dr. Oliver Smithies discusses the present and future of genetic engineering

Show notes

Comments and suggestions on Futures in Biotech.

For a free audiobook, visit Audible.com/biotech.

Transcripts to the shows are available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 55:06">

Hosts: Marc Pelletier and Dave Brodbeck

An interview with Dr. Terrence Sejnowski about theoretical and computational biology and neurobiology.

Guest: Terrence Sejnowski of the Salk Institute

Show notes

Audible pick: This Is Your Brain on Music: The Science of a Human Obsession, Abridged, By Daniel J. Levitin, Narrated by Edward Herrman. For a free audiobook, visit Audible.com/biotech.

Comments and suggestions on Futures in Biotech.

Transcripts to the shows are available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 56:25

Hosts: Marc Pelletier

Guest: Dr. Oliver Smithies; Professor, Department of Pathology and Lab Medicine University of North Carolina at Chapel Hill

Marc talks with Dr. Oliver Smithies, 2007 Nobel Laureate, and father of mammalian genetic engineering.

Show notes wiki

Comments and suggestions on Futures in Biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 51:06

Hosts: Marc Pelletier, Dave Brodbeck

Guest: John Gabrieli; Grover Herman Professor of Health Sciences and Technology and Professor of Brain and Cognitive Sciences, Massachusetts Institute of Technology (MIT)

Looking directly into the human mind with fMRI technology.

Show notes wiki

Comments and suggestions on Futures in Biotech.

Audible pick: Meditations on First Philosophy: With Selections from the Objections and Repiles, Unabridged, By Rene Descartes, Narrated by Paul Hecht. For a free audiobook, visit Audible.com/biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:09:39

Host: Marc Pelletier, Ph.D.

Panelists: Drs. Vincent Racaniello, Andre Nantel, Justin Sanchez, and Dave Brodbeck.

From wooly mammoths, to cybernetics, and controlling your computer with your brain, a panel discusses the recent big stories in bioscience.

Show notes wiki

Comments and suggestions on Futures in Biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:28:27

Hosts: Dr. Marc Pelletier and Randal Schwartz

An interview with the host of This Week in Virology, Vincent Racaniello, on the topic of Swine Flu.

Guest: Dr. Vincent Racaniello, Ph.D., is a professor of Microbiology at the Columbia University Medical Center and the host of This Week in Virology.

Show notes wiki

Comments and suggestions on Futures in Biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:03:47

Hosts: Dr. Marc Pelletier and Randal Schwartz

A follow-up look at Folding@Home, the world's most powerful distributed computing cluster, designed to perform computationally intensive protein folding simulations.

Guest: Dr. Vijay S. Pande, Director of Folding@Home and Associate Professor of Chemistry and of Structural Biology, Stanford University

Audible pick: Always Looking Up: The Adventures of an Incurable Optimist, Abridged, By Michael J. Fox, Narrated by Michael J. Fox. For a free audiobook, visit Audible.com/biotech.

Show notes wiki

Comments and suggestions on Futures in Biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:16:52

Hosts: Dr. Marc Pelletier and Vincent Racaniello

Leading virologist Peter Palese explains why he revived a virus that killed 50 million people.

Guest: Peter Palese, professor and chair of microbiology at the Mount Sinai School of Medicine in New York.

In the winter of 1918-19, fifty million people died horrible deaths from the Spanish flu. The threat of this happening again today is ever so present. And while we have drugs that are fairly effective against influenza, they are not foolproof.

The possible devastation to humanity from this threat is extremely significant. The world will look to the best and brightest scientists and clinicians in hopes that they know and understand the virus well enough to fight it.

Dr. Palese has made great contributions to our understanding of influenza, and his scientific endeavors have given us the knowledge and tools to prevent this potential devastation.

Show notes wiki

Comments and suggestions on Futures in Biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:09:20

Host: Dr. Marc Pelletier

Dr. Lisa Weasel discusses the controversies surrounding genetically-modified foods.

Guest: Dr. Lisa Weasel, associate professor of biology at Portland State University in Oregon, a member of Governor Ted Kulongoski's task force on developing public policy for bio-pharmaceutical crops in Oregon, and author of Food Fray: Inside the Controversy over Genetically Modified Foods.

Why isn't there a wide consumer acceptance of genetically modified (GM) foods? If we can design crops that reduce pesticides, grow more effectively in poor soil, bring nutrients such as vitamins A to populations with high incidences of blindness, or even just taste better, why are we hesitating?

Audible pick: On the Origin of Species, Abridged, By Charles Darwin, Narrated by Richard Dawkins. To sign up for a free audiobook, visit Audible.com/biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 48:04

Hosts: Dr. Marc Pelletier and Dr. Glen Ernstrom

Guest:Dr. Martin Chalfie; Professor and Chair of the Department of Biological Sciences, Colombia University, New York, NY.

This is Part II of our conversation with Dr. Martin Chalfie. In this episode Dr. Chalfie shares the historical account of his contribution to the 2008 Nobel Prize in Chemistry: How he transformed a green fluorescent jellyfish protein into the most important biological marker used today, one that allows us to track the life of recombinant protein in a living cell.

Audible pick: The Ten Most Beautiful Experiments, by George Johnson, Narrated by dion Graham. To sign up for a free audiobook, visit Audible.com/biotech.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 51:40

Hosts: Marc Pelletier and Dr. Glen Ernstrom

Guest: Marty Chalfie, 2008 Nobel Laureate in Chemistry

This episode covers how Marty Chalfie discovered the molecular machinery that senses touch. In Part II, Chalfie describes how he developed one of the most important tools of modern molecular biology, one that allows us to see inside a living cells, down to the protein level. With green fluorescent protein, or GFP, we can now track the life of a protein, from when the gene that makes the protein is turned on, to where it goes, to where it dies.

Audible Pick: The Snows of Kilimanjaro and Other Stories, Abridged, By Ernest Hemingway, Narrated by Stacy Keach.

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 57:56

Host: Marc Pelletier

Guest: Dr. Cynthia Kenyon; Professor, Department of Biochemistry and Biophysics, University of California San Francisco, Director of the Larry L. Hillblom Center for the Biology of Aging.

We are back into a world leading lab to discuss the genetics of aging. Can it be controlled? You bet, and the implications are enormous. When these findings translate to the clinic, it will truly be a game changer for humanity.

Some interesting links:
sirtrispharma
Elixir
Sirtris

Audible Pick: Prey by Michael Crichton.

For a 30 day free trial visit GotoMeeting

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint

Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:01:21

Host: Marc Pelletier

Dr. Justin Sanchez discusses technologies that enable direct brain to computer interfacing, just think…

Guest: Dr. Justin C. Sanchez, Director of the Neuroprosthetics Research Group, Assistant Professor, Department of Pediatrics, Division of Neurology, Department of Neuroscience, Department of Biomedical Engineering, University of Florida.

I really had no idea that the technologies that Justin has developed existed other than in science fiction. The possibilities are endless, and could change everything from computing, to flying planes, to simply changing the channel… I will keep these notes short, and let Justin explain.

Find more, including videos at: The Neuroprosthetics Research Group

Transcripts to the shows are now available on the FiB Extras blog thanks tom.price@podsinprint.com, PodsinPrint. Also thanks to Phil Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 50:11

Host: Marc Pelletier

Mark Gerstein endeavors to make sense our genome on its past and present course.

Guest: Mark Gerstein, the Albert L. Williams Professor of Biomedical Informatics, a professor of Molecular Biophysics and Biochemistry and professor of Computer Science at Yale University Gerstein Lab.

In past shows, we've had Lee hood, the inventor of the DNA sequencer, and George Church who was among those personally involved in initiating the Human project. But getting the code and really understanding these human blueprints are entirely different problems. Our guest today, Mark Gerstein, is trying to make sense of it all, and his work amoung other things has revealed that the genome is more than just a blueprint, or list of parts, but a rich historical text about our past.

BLAST this sequence: atgttcc tgtccttccc caccaccaag acctacttcc cgcacttcga cctgagccac ggctctgccc aggttaaggg ccacggcaag aaggtggccg acgcgctgac caacgccgtg gcgcacgtgg acgacatgcc caacgcgctg tccgccctga gcgacctgca cgcgcacaag cttcgggtgg acccggtcaa cttcaagctc ctaa

Instructions: Copy and Paste the DNA sequence into the query window, and hit the blast button. What does this encode? Interesting: Try again selecting the NON-HUMAN database. What organism is the exact same gene found in? Why?

Audible pick of the week: Legacy of Ashes: The History of the CIA, Unabridged, By Tim Weiner, Narrated by Stefan Rudnicki. For your free audio book visit Audible.com/biotech.

TWiT T-Shirts from Lori LeBeau Walsh.

Transcripts to the shows are now available on the FiB Blog thanks to the kind folks at PodsinPrint.

Also thanks to Philippe Pelletier and Will Hall for the great themes.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 55:35

Host: Marc Pelletier

Dr. Brenda Milner describes the experiments that led to a revolution in modern neuroscience.

Guest: Dr. Brenda Milner; Dorothy J. Killam Professor of Psychology, Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

Throughout her 58 years at the Montreal Neurological Institute, Dr. Milner has explored the inner workings of the human mind, and helped define the structures that give us our exquisite memory and ability for leaning. Her groundbreaking work has influenced generations of psychologists and neuroscientists, and through her unbridled curiosity has revealed many facets to the human mind that were previously unknown.

• Gairdner Foundation
• Gairdner News
• Dr. Milner on Wikipedia

Audible pick of the week: Starswarm by Dr. Jerry Pournelle, narrated by Lloyd James. For your free audio book visit Audible.com/biotech.

Transcripts to the shows are now available on the FiB Blog thanks to the kind folks at PodsinPrint.

Thanks to Cachefly for providing the bandwidth for this netcast.

Running time: 1:12:37

Host: Marc Pelletier

Dr. Ronald Collman talks about exciting new discoveries on HIV, the virus that has taken 25 million lives.

Guest: Dr. Ronald Collman, professor of medicine in microbiology, virus/cell/molecular core director, Penn Center for AIDS Research, University of Pennsylvania.

It looks like the summer of 2008 will be an amazing summer for science. The Phoenix Mars Mission and NASA have successfully landed their probe on the Martian arctic, in search for the conditions that can sustain life (FiB24), the personal genome project, run by Dr. George Church, is braving us forward into a new era human genomics (FiB29), and lastly, the Large Hadron Collider (LHC) is getting readied to explore the origins of the Big Bang, and may just unravel the ultimate theory of everything (FiB31).

Nevertheless, a large cloud hangs over humanity, which has taken over 25 million lives (warning: hardcore biotech discussion). Dr. Ronald Collman describes the molecular structure, pathology, and with great insight, the incredible discoveries that might just help us conquer HIV.

Software pick: Papers

Audible pick: Freakonomics: A Rogue Economist Explores the Hidden Side of Everything by Steven D. Levitt and Stephen J. Dubner. For your free audio book visit Audible.com/biotech.

Transcripts to the shows are now available on the FiB Blog thanks to the kind folks at PodsinPrint

Thanks to Cachefly for providing the bandwidth for this netcast.

Also thanks to Will Hall for the great theme.

Running time: 49:46

Host: Marc Pelletier

Guest: Dr. Michio Kaku, Henry Semat Professor of Theoretical Physics at the Graduate Center of the City University of New York.

In this episode, we are very fortunate to have Dr. Michio Kaku. He is the co-founder of String Field Theory, and a Professor of Theoretical Physics at City Univerity in NY. In our discussion he talks about everything, literally: the theory of EVERYTHING! I must say, if we are going to have a true understanding of the living world, it will demand an understanding our universe and how it 's assembled. You can't separate out the laws of physics from biology, they go hand in hand. Dr. Kaku also talks about the current teleportation experiments to the space shuttle, and how we might some day be able to teleport DNA. Seriously, that is some BIOTECH!!!

Dr. Kaku's Book:
Physics of the Impossible: A Scientific Exploration into the World of Phasers, Force Fields, Teleportation, and Time Travel

Our Audible Pick of the week: Born Standing UP: A Comic's Life by Steve Martin. For your free audio book visit Audible.com/biotech.

Transcripts to the shows are now available on the FiB Blog thanks to the kind folks at PodsinPrint

Thanks to Cachefly for providing the bandwidth for this netcast.

Also thanks to Will Hall for the great theme.

Running time: 54:23

Host: Marc Pelletier

Guest: Aubrey de Grey; Chairman and Chief Science Officer, the Methuselah Foundation.

Benjamin Franklin said: “In this world nothing is certain but death and taxes�. But in these times of technological revolution, does this statement still hold true? And if so, for how long? Genes have been identified that upon activation can extend lifespan in most organisms. The great labs of Leonard Guarente at MIT (featured in FiB episode 2), Cynthia Kenyon at UCSF, as well Linda Buck, Nobel Laureate in 2004, are all working arduously to elucidate the molecular details to both slow down the aging process and extend lifespan. Well, Aubrey de Grey is a fairly controversial figure because he proposes doing away with death all together - leaving us with only taxes, I guess?

Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime, by Aubrey de Grey.

Audible.com Pick of the Week: The Age of Turbulence: Adventures in a New World by Alen Greenspan. For your free audio book visit Audible.com/biotech.

Thanks to Cachefly for providing the bandwidth for this netcast.

Also thanks to Will Hall for the great opening and closing themes.

Running time: 1:04:05

This Author: Marc Pelletier

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